The idea of establishing a Weapons of Mass Destruction or Nuclear Weapon Free Zone in the Middle East is not new; it dates back to 1970’s. However, the security landscape of the Middle East today has compelled most analysts to look at the idea and the concept anew. Most regard the potential arms race in the Middle East to seriously jeopardize the prospects for long term stability and balance of power in the region. Israel, Iran and Egypt seem to have the main regional role in making or breaking this idea for another forty years. The absence of real progress in the Arab-Israeli conflict and the hesitant international expectation to make some movements in that front, as well as Iran’s nuclear program being considered at the UN Security Council, where Iran is being practically considered guilty until proven innocent, may offer a window of opportunity to creative thinking and planning for advancing the idea of Weapons of Mass Destruction Free Zone in the Middle East.