Since the Islamic Revolution in Iran, the state of interaction between Tehran and Washington has seen considerable ups and downs. Conflict between the Islamic Republic of Iran's national interests and those of the United States gave rise to the dominance of strategic confrontation between the two states, though some cooperative actions have been witnessed between the two sides. The last example refers to some collaboration between Iran and the United States concerning the question of Afghanistan. In this article, we seek to analyze the trend governing the two actors' behavior in the region between 2001 and 2009, using a historical approach and considering the Taliban's agency.